The music video for "Please Don't Leave Me" was shot in late 2008, leaked to the internet on January 23, 2009, and officially premiered on Pink's YouTube channel on January 27, 2009. It was directed by Dave Meyers. A highly unique and unusual music video, it draws influences from the 1990 Stephen King based film Misery, as well as other similar thrillers. It utilizes both the horror/thriller genre, while also being interpretable as a dark comedy. In the week beginning February 27 the video was named Channel V's 'Ripe' clip of the week.

The male lead in the video was portrayed by actor Eric Lively. Brian Christensen served as stunt coordinator, Nikki Hester as stunt double for Pink, and Justin Sundquist as stunt double for Eric Lively.

It begins inside Pink's house, where after a fight with her boyfriend, she is shown trying to stop him from packing his stuff in preparation to leave. He exits the bedroom with his bags, and as he reaches the stairway Pink pleads with him to stay. He refuses and turns to leave. As he does so, he slips on some marbles on the floor and endures a rough fall down the stairs. He sees Pink coming towards him down the stairs, with an innocent expression on her face, and blacks out. He awakens, bruised and swollen in bed with Pink dressed in a nursing type of uniform, stitching up one of his wounds. She dances suggestively for him, while he tries to grasp for the telephone at the bedside, only to have Pink smash his kneecaps with a golf club (a direct imitation of one of the scenes from the aforementioned movie Misery).

Pink is then shown in the kitchen preparing a salad, rapidly and angrily chopping the vegetables with a large knife. Her boyfriend awakens in bed, and attempts to sneak out through the door, but Pink catches him at the doorway. She gives him a bewildered look while holding the bowl of salad, as he debates whether or not he can escape. He opens the door, only to be instantly attacked by one of Pink's dogs. He is next shown opening his eyes to Pink's face yet again, as she paints his face with clownish makeup, while he sits in a wheelchair. She is wearing another lavish outfit. His hands are tied, and he is bruised and battered almost beyond recognition. Pink grabs his wheelchair, spins it around a few times and pushes it off a high step, seeming to enjoy herself in the process. He flies out of the chair, into a room filled with carnival themed objects such as horses used in a merry go round and various dolls. Pink lays on top of him, acting completely innocent, and kissing his cheek. He manages to crawl out from under and begins to attempt another escape.

Pink chases him into the garage, where she grabs an axe and continues to stalk him through the house. He reaches the upstairs bathroom, and shuts the door just in time to block Pink charging psychotically down the hallway with the axe. The axe breaks through the wood, leaving a hole in the door. Pink looks in though the hole (a direct imitation from the Stephen King based film, "The Shining" ), as the guy grabs a spray can, spraying her in the eyes. Blinded, she flails backwards, and slips on the marbles from the beginning of the video, falling over the upstairs railing. The final scene shows the paramedics taking the man out on a stretcher, and Pink lying on the floor with her leg broken and the axe beside her. She gives him one final look of desperation not to leave as he is wheeled out, before blowing a kiss to the camera with a comically, psychotic look on her face.

The music video first aired on UK television on 4Music on March 8th, 2009 at 10:45pm^. It showed the full video, uncensored.

Censored version

An edited ("censored") version of the music video has been released, which cuts roughly 11 seconds of footage, but includes some footage not previously used.

The censored version does not show Pink's boyfriend falling down the stairs, it shows Pink at the top of the stairs. When he is in the bed the sewn stitches on his arm are not shown. The part when Pink hits his leg with the golf club has also been removed. It then cuts to when Pink is chopping vegetables a few seconds earlier than the original and is on for a few seconds longer.

When the guy is in the wheelchair, it doesn't show him being pushed by Pink. Instead, it shows him being twirled in the wheelchair by Pink. The next scene is when Pink is on top of him on the toys kissing his cheek. The part where Pink is holding an axe is not there, it shows the guy looking back, looking for Pink and hopping, trying to get away from her.

The next scene is when the guy is in the bathroom looking for something to do to get him out, he grabs the spray can. Next, we see Pink falling on marbles, as she goes over the railings and lands on her back on the floor. The video ends as the original.