In the music video for Family Portrait, Pink plays a young woman who still has unresolved issues with her parents' divorce. This is represented by a little girl representing Pink as a child, played by actress Kelsey Lewis. Throughout the video, Pink's younger self tries to get her to address her childhood, in many ways such as making her eat cereal she liked as a child and interfering with her therapy session. Pink initially refuses to listen to her younger self until the bridge. After that, Pink comes to terms with her childhood as represented by her younger self joining the family in the television.

Another interpretation of the video: Pink is a young woman willing to divorce her husband, who is an unknown character in the video. The little girl is her daughter and sings most of the verses in the song trying to convince her mother to reconsider her decision. The video starts with Pink waking up to answer the phone. She breaks a glass of water as she reaches the phone. The little girl sings the first verse and the video moves to another scene where Pink and her daughter argue about the divorce. The girl pulls her mother (Pink) by the hand asking her "Can we work it out?", Pink replies "Get away". As the second verse starts, Pink and her daughter are shown sitting on a sofa, eating cereal and watching TV. The girl sings verse 2 as she and her mom watch a happy family of a Mother, a Father, two girls and a boy eating cereal all together, in a kitchen of bright colors. In the middle of the video, a lawyer visits the family and Pink discusses her divorce matters with him as her daughter tries her best to stop her, and the lawyer notices the girl's behavior. After he leaves, Pink and her daughter sit on the stairs wearing the same outfit and singing the chorus. Then the two girls sing each individually. As the bridge starts, Pink is singing and her daughter is shown happy with what her mom is saying about the effects of divorce on a kid. Then they're both shown playing on the sofa (where they ate cereal) and in a good mood showing Pink has backed off the idea of divorce. But then, the mother in TV outstretches her hand toward Pink's daughter and invites her to join the family, and the girl gives her her hand and joins her. The video ends with Pink lying on the sofa alone and holding to her pillow tight.